LINC complex

The LINC complex (Linker of Nucleoskeleton and Cytoskeleton) is a protein complex associated with both inner and outer membranes of the nucleus. It is composed of SUN-domain proteins and KASH-domain proteins. The SUN-domain proteins are associated with both nuclear lamins and chromatin and cross the inner nuclear membrane. They interact with the KASH-domain proteins in the perinuclear (lumen) space between the two membranes. The KASH domain proteins cross the outer nuclear membrane and interact with actin filaments, microtubule filaments (through dynein and kinesin motors), intermediate filaments (through spectrin), centrosomes and cytoplasmic organelles. The number of SUN-domain and KASH-domain proteins increased in evolution.

Function

The function of the LINC complex appears to be in many cell activities. These include nuclear relocation/movement, moving meiotic chromosomes to find their homologues at leptotene/zygotene, attaching the centrosome to the outer nuclear membrane and responding to extracellular mechanical stimuli. LINC complex, by virtue of providing internal cell connectivity, is required for sensing of various mechanical stimuli including high frequency vibrations.

Complex

Complex may refer to:

Biology

Chemistry

Mathematics

Complex (band)

Complex was a Japanese rock duo composed of guitarist Tomoyasu Hotei and singer Koji Kikkawa. They released their self-titled debut in 1989, along with their first single and video, "Be My Baby". After a tour to promote the album, they released its follow-up, Romantic 1990, followed by a live album, 19901108 a year later.

The concert immortalized on the 19901108 CD and video turned out to be their last. They broke up sometime after the show, and in an interview Hotei said that the experience of Complex ended his friendship with Kikkawa (equating it to a divorce) and that he thought the whole thing was "a mistake". To date, neither Hotei nor Kikkawa has elaborated on the reason behind the band's breakup.

Following the band's breakup, both Hotei and Kikkawa continued their solo careers.

The band's label Toshiba EMI released a greatest hits compilation called Complex Best in 1998, and a DVD re-issues of their video catalog, which are currently out of print.

On April 28, 2011, it was announced that after 21 years, Kikkawa and Hotei would reunite for a Complex show on July 30 and 31st at the Tokyo Dome. All proceeds were donated to aid the victims of the Tōhoku earthquake and tsunami. The performance was released on CD, DVD and Blu-Ray in 2012.

Complex (psychology)

A complex is a core pattern of emotions, memories, perceptions, and wishes in the personal unconscious organized around a common theme, such as power or status. Primarily a psychoanalytic term, it is found extensively in the works of Carl Jung and Sigmund Freud.

An example of a complex would be as follows: if you had a leg amputated when you were a child, this would influence your life in profound ways, even if you were wonderfully successful in overcoming the handicap. You might have many thoughts, emotions, memories, feelings of inferiority, triumphs, bitterness and determinations centering on that one aspect of your life. If these thoughts troubled you, Jung would say you had a complex about the leg.

Complex existence is widely agreed upon in the area of depth psychology. It assumes the most important factors influencing your personality are deep in the unconscious. They are generally a way of mapping the psyche, and are crucial theoretical items of common reference to be found in therapy. Complexes are believed by Carl Jung and Sigmund Freud to influence the individual's attitude and behavior.

Alinja

Alinja (also known as "Alıncak"; Azerbaijani: Əlincə; Armenian: Երնջակ, Yernjak or Ernjak) is a village and municipality in the Julfa Rayon of Nakhchivan, Azerbaijan. It has a population of 634. The mausoleum and shrine of the Hurufi Fazlallah are located on a hillside overlooking the village. Qara Iskander, the ruler of Kara Koyunlu was murdered there in 1436 by his son Shah Kubad.

History

Alinja is mentioned in historical records for the first time in the seventh century atlas, the Ashkharhatsuyts, commonly attributed to Anania Shirakatsi, under its original Armenian name, Yernjak. It is described as the first district of the Kingdom of Armenia's province of Syunik'. The ruins of the medieval Yernjak (or Ernjak) fortress, which dates to the seventh century, are located on a crag overlooking Alinja village. This fortress once controlled, and gave its name to, Yernjak province, which comprised the whole valley down to the Araks river. A separate Armenian tradition states that the province was named after Lady Yernjik, a member of the royal family of the Syunik' princes. The Armenian historian Stepanos Orbelian noted its formidable position, describing it as the "impossible to penetrable Yernjak" (անհնարին ամուրն Երնջակ).

LINC

The LINC (Laboratory INstrument Computer) is a 12-bit, 2048-word computer. The LINC is considered the first minicomputer and a forerunner to the personal computer. Originally named the "Linc", suggesting the project's origins at MIT's Lincoln Laboratory, it was renamed LINC after the project moved from the Lincoln Laboratory. The LINC was designed by Wesley A. Clark and Charles Molnar.

The LINC and other "MIT Group" machines were designed at MIT and eventually built by Digital Equipment Corporation (DEC) and Spear Inc. of Waltham, Massachusetts (later a division of Becton, Dickinson and Company). The LINC sold for more than $40,000 at the time. A typical configuration included an enclosed 6'X20" rack, four boxes holding tape drives, a small display, a control panel, and a keyboard.

Although the LINC's instruction set was small, it was larger than the tiny PDP-8 instruction set.

The LINC interfaced well with laboratory experiments. Analog inputs and outputs were part of the basic design. It was designed in 1962 by Charles Molnar and Wesley Clark at Lincoln Laboratory, Massachusetts, for NIH researchers. The LINC's design was literally in the public domain, perhaps making it unique in the history of computers. The number of LINCs and who built them is a minor subject of debate in the 12-bit-word community. One account states that a dozen LINC computers were assembled by their eventual biologist users in a 1963 summer workshop at MIT.Digital Equipment Corporation (starting in 1964) and Spear Inc. of Waltham, MA. manufactured them commercially.