LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.
The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.
Leukemia inhibitory factor receptor has been shown to interact with Glycoprotein 130.
LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.
A slap to the face when you don't get your way
You tell me all about your situation Please keep to
Yourself
I don't want to hear you but you keep on telling me
I'm sick of you
Don't worry about me
You think about yourself so much
You always think it's all about you, Don't worry about me
You think about yourself, so much.
Do you like what you have?
Now I'm taking it back
I wonder if you even know what you say
You bore me with your selfish conversation
Please keep to yourself
No one wants to hear you but you keep on telling me
I'm sick of you
Don't worry about me
You think about yourself so much
You always think it's all about you, Don't worry about me
You think about yourself, so much.
Do you like what you have?
I'm gonna take it away
If you come back down
Will you listen to me?
When you come back down