Lgiń

Lgiń [lɡiɲ] is a village in the administrative district of Gmina Wschowa, within Wschowa County, Lubusz Voivodeship, in western Poland. It lies approximately 10 kilometres (6 mi) north-west of Wschowa and 52 km (32 mi) east of Zielona Góra.

The village has a population of 480.

References

Coordinates: 51°52′37″N 16°14′44″E / 51.87694°N 16.24556°E / 51.87694; 16.24556

LGI2

Leucine-rich repeat LGI family member 2 is a protein that in humans is encoded by the LGI2 gene.

References

Further reading

LGI1

Leucine-rich, glioma inactivated 1, also known as LGI1, is a protein which in humans is encoded by the LGI1 gene. It may be a metastasis suppressor.

Function

The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas.

Clinical significance

Since its earliest discovery, the LGI1 gene has been implicated in the control of cancer metastasis and in a predisposition to epilepsy. Following genetic linkage studies placing the hereditary form of autosomal dominant partial epilepsy with Auditory features (ADPEAF) on chromosome region 10q24 mutation analysis of affected members in these families demonstrated LGI1 was the cause of the disease.