LDL receptor
The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100, which is embedded in the outer phospholipid layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). In humans, the LDL receptor protein is encoded by the LDLR gene. It belongs to the Low density lipoprotein receptor gene family.
Michael S. Brown and Joseph L. Goldstein were awarded the 1985 Nobel Prize in Physiology or Medicine for their identification of the Low Density Lipoprotein (LDL) Receptor and its relation to cholesterol metabolism and familial hypercholesterolemia.
Clinical significance
LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.
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by Lea Delaria
Welcome to My Party
by: Lea DelariaWelcome to my party
Glad you stumbled in
Welcome to my party
Baby, where's the ice?
Who here's up for dancing?
Who here's new?
Welcome to party
Who the hell invited you?
You're here 'cause you love me
Don't I know it? Yeah, I know
You're here because you love me
'Cause the booze is cheap and the low down's low
Welcome to my party
You know what I need
Queenie's up for jazzin'
Queenie's up for anything tonight
I gotta get my engines smokin'
I need it bad, God, I need it more
I need a lot of friendly strokin'
'Cause there ain't no heaven and there ain't no hell
No turning back, gotta lock the door
Welcome
Creatures of the night
Have come here to play
We don't need the light
And we don't like the day
People like us
Gotta jazz till we drop
'Cause people like us
We don't know when to stop
I know how to party
Show you how it's done
I'll teach you to party
Where the hell's my ice?
You remember this one
Queenie's guaranteed
Welcome to my party
Wanna get creamed?
Wanna get juiced?
Want to get wild?
Follow me, follow me
Welcome