LCN2
Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), is a protein that in humans is encoded by the LCN2 gene. NGAL is involved in innate immunity by sequestrating iron that in turn limits bacterial growth. It is expressed in neutrophils and in low levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts. NGAL is used as a biomarker of kidney injury.
Function
The binding of NGAL to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of NGAL. Secreted NGAL then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 binds, next to bacterial siderophores, also to the mammalian siderophore 2,5-dihydroxybenzoic acid (2,5-DHBA). This complex ensures that excess iron is transported out of the cytoplasm into the extracellular space. Mammalian cells lacking 2,5-DHBA accumulate abnormal intracellular levels of iron leading to high levels of reactive oxygen species. Lipocalin-2 also functions as a growth factor.
Podcasts:
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by Darin Zanyar
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by Princessa
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by Darin
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by Victory At Sea
Like No One
by: Darin ZanyarI really thought I got it this time,
I never knew a thing like this could end
I guess I'm really back to nothing
To what they use to call square one
(I'm starting all over)
Waking up alone again now
Staring at the phone and wondering how
Reading all the letters once more
Try to figure out how this could be
(All over so over)
But then there is that someone
Wherever I'm turning she's there
Like no one
You take the pain away
Like the sun
Lighting up my everyday
You are the sun the only one
Like no one
You stay around for me
Like the sun
Lighting up the way for me
You are the sun the only one you are the sun oh
I know I really shouldn't do this
I really shouldn't make the same mistake
(All over we've been there)
I don't even wanna do it
It's just a way of keeping thoughts away
(An easy solution)
It'll always be that someone
Wherever I'm turning she's there
Like no one
You take the pain away
Like the sun
Lighting up my everyday
You are the sun the only one
Like no one
You stay around for me
Like the sun
Lighting up the way for me
You are the sun the only one you are the sun
You are the sun
The only one I turn to in need
You are the sun
The only one I truly believe oh
Like no one
You take the pain away
Like the sun
Lighting up my everyday
You are the sun the only one
Like no one
You take the pain away
Like the sun
Lighting up my everyday
You are the sun the only one
Like no one
Like the sun