Lamp2

Lysosomal-associated membrane protein 2

Identifiers

LAMP2; CD107b; LAMP-2; LAMPB; LGP110

External IDs

OMIM: 309060 MGI: 96748 HomoloGene: 7809 GeneCards: LAMP2 Gene

Gene Ontology
Cellular component	• membrane fraction • lysosome • lysosome • lysosomal membrane • late endosome • late endosome • plasma membrane • endosome membrane • membrane • integral to membrane • phagocytic vesicle membrane • platelet dense granule membrane • platelet dense granule membrane
Biological process	• platelet degranulation • blood coagulation • platelet activation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
119.56 – 119.6 Mb

Chr X:
35.75 – 35.81 Mb

PubMed search

[1]

[2]

Lysosomal-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene.

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of the gene produces two known products of unknown function. ^[1] Recently it has been determined that antibodies against LAMP-2 account for a fraction of patients who get a serious kidney disease termed focal necrotizing glomerulonephritis.

It is associated with Danon disease.

1 See also
2 References
3 Further reading
4 External links

References [link]

^ "Entrez Gene: LAMP2 lysosomal-associated membrane protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3920.

Further reading [link]

Chang MH, Karageorgos LE, Meikle PJ (2003). "CD107a (LAMP-1) and CD107b (LAMP-2).". J. Biol. Regul. Homeost. Agents 16 (2): 147–51. PMID 12144129.
Schleutker J, Haataja L, Renlund M, et al. (1992). "Confirmation of the chromosomal localization of human lamp genes and their exclusion as candidate genes for Salla disease.". Hum. Genet. 88 (1): 95–7. DOI:10.1007/BF00204936. PMID 1959930.
Manoni M, Tribioli C, Lazzari B, et al. (1991). "The nucleotide sequence of a CpG island demonstrates the presence of the first exon of the gene encoding the human lysosomal membrane protein lamp2 and assigns the gene to Xq24.". Genomics 9 (3): 551–4. DOI:10.1016/0888-7543(91)90424-D. PMID 2032724.
Carlsson SR, Fukuda M (1990). "The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.". J. Biol. Chem. 265 (33): 20488–95. PMID 2243102.
Mattei MG, Matterson J, Chen JW, et al. (1990). "Two human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2, are encoded by genes localized to chromosome 13q34 and chromosome Xq24-25, respectively.". J. Biol. Chem. 265 (13): 7548–51. PMID 2332441.
Mane SM, Marzella L, Bainton DF, et al. (1989). "Purification and characterization of human lysosomal membrane glycoproteins.". Arch. Biochem. Biophys. 268 (1): 360–78. DOI:10.1016/0003-9861(89)90597-3. PMID 2912382.
Fukuda M, Viitala J, Matteson J, Carlsson SR (1989). "Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.". J. Biol. Chem. 263 (35): 18920–8. PMID 3198605.
Dahlgren C, Carlsson SR, Karlsson A, et al. (1995). "The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils.". Biochem. J. 311 (2): 667–74. PMC 1136051. PMID 7487911. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1136051.
Konecki DS, Foetisch K, Zimmer KP, et al. (1995). "An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner.". Biochem. Biophys. Res. Commun. 215 (2): 757–67. DOI:10.1006/bbrc.1995.2528. PMID 7488019.
Konecki DS, Foetisch K, Schlotter M, Lichter-Konecki U (1995). "Complete cDNA sequence of human lysosome-associated membrane protein-2.". Biochem. Biophys. Res. Commun. 205 (1): 1–5. DOI:10.1006/bbrc.1994.2620. PMID 7999007.
Carlsson SR, Lycksell PO, Fukuda M (1993). "Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.". Arch. Biochem. Biophys. 304 (1): 65–73. DOI:10.1006/abbi.1993.1322. PMID 8323299.
Sawada R, Jardine KA, Fukuda M (1993). "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.". J. Biol. Chem. 268 (12): 9014–22. PMID 8517882.
Kannan K, Stewart RM, Bounds W, et al. (1996). "Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium.". Cell. Immunol. 171 (1): 10–9. DOI:10.1006/cimm.1996.0167. PMID 8660832.
Israels SJ, McMillan EM, Robertson C, et al. (1996). "The lysosomal granule membrane protein, LAMP-2, is also present in platelet dense granule membranes.". Thromb. Haemost. 75 (4): 623–9. PMID 8743190.
Aumüller G, Renneberg H, Hasilik A (1997). "Distribution and subcellular localization of a lysosome-associated protein in human genital organs.". Cell Tissue Res. 287 (2): 335–42. DOI:10.1007/s004410050758. PMID 8995204.
Akasaki K, Michihara A, Fujiwara Y, et al. (1997). "Biosynthetic transport of a major lysosome-associated membrane glycoprotein 2, lamp-2: a significant fraction of newly synthesized lamp-2 is delivered to lysosomes by way of early endosomes.". J. Biochem. 120 (6): 1088–94. PMID 9010755.
Karlsson K, Carlsson SR (1998). "Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct from mannose 6-phosphate receptor/gamma-adaptin vesicles at the trans-Golgi network.". J. Biol. Chem. 273 (30): 18966–73. DOI:10.1074/jbc.273.30.18966. PMID 9668075.
Ayala P, Lin L, Hopper S, et al. (1998). "Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents.". Infect. Immun. 66 (10): 5001–7. PMC 108621. PMID 9746610. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108621.
Furuta K, Yang XL, Chen JS, et al. (1999). "Differential expression of the lysosome-associated membrane proteins in normal human tissues.". Arch. Biochem. Biophys. 365 (1): 75–82. DOI:10.1006/abbi.1999.1147. PMID 10222041.
Nishino I, Fu J, Tanji K, et al. (2000). "Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease).". Nature 406 (6798): 906–10. DOI:10.1038/35022604. PMID 10972294.

External links [link]

LAMP2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v t e Peroxisomal and lysosomal proteins

Enzymes	Mevalonate kinase · Catalase · Acetyl-CoA C-acyltransferase · Glyceronephosphate O-acyltransferase · Alkylglycerone phosphate synthase · Phytanoyl-CoA hydroxylase · HSD17B4 · AMACR

Transporters	SLC27A2

Structure/Peroxin	PEX1, PEX2 - PXMP3, PEX3, PEX5, PEX6, PEX7, PEX10, PEX11A, PEX11B, PEX11G, PEX12, PEX13, PEX14, PEX16, PEX19, PEX26

LAMP	CD68 · LAMP1 · LAMP2 · LAMP3

see also intermediates, disorders B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)

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See also [link]

References [link]

Further reading [link]

External links [link]

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