L-759,633

L-759,633 is an analgesic drug that is a cannabinoid agonist. It is a fairly selective agonist for the CB₂ receptor, with selectivity of 163x for CB₂ over CB₁.

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB₁ activity, and a relatively strong antiinflammatory effect due to its strong activity at CB₂.

References

↑ Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG (1999). "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630". British Journal of Pharmacology 126 (3): 665–72. doi:10.1038/sj.bjp.0702351. PMC 1565857. PMID 10188977.

↑ Huffman JW (2000). "The search for selective ligands for the CB2 receptor". Current pharmaceutical design 6 (13): 1323–37. doi:10.2174/1381612003399347. PMID 10903395.

↑ Huffman JW (2005). "CB2 receptor ligands". Mini reviews in medicinal chemistry 5 (7): 641–9. doi:10.2174/1389557054368844. PMID 16026310.

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