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Karst Plateau

The Karst Plateau or the Karst region (Italian: Carso; Slovene: Kras), also simply known as the Karst, is a limestone plateau region extending across the border of southwestern Slovenia and northeastern Italy.

It lies between the Vipava Valley, the low hills surrounding the valley, the westernmost part of the Brkini Hills, northern Istria, and the Gulf of Trieste. The western edge of the plateau also marks the traditional ethnic border between Italians and Slovenes. The region gave its name to the karst topography. For this reason, it is also referred to as the Classical Karst.

Geographical position

The plateau rises quite steeply above the neighboring landscape, except for its northeastern side, where the steepness is less pronounced. The plateau gradually descends from the southeast to the southwest. On average it lies 334 m above sea level. Its western edge, known as the Karst Rim (Slovene: Kraški rob), is a continuation of the Učka mountain range in eastern Istria, and rises to the east and southeast of Trieste, ending in steep cliffs between Aurisina and Duino. Many interesting geological phenomena occur along the Karst Rim, including the picturesque Rosandra Valley (also known as Glinščica).

Kras (disambiguation)

Kras is a limestone borderline plateau region in southwestern Slovenia.

Kras may refer to:

  • KRAS - a protein V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
  • Kras Stadion, a stadium in Volendam, Netherlands
  • Kraš, Croatian food company
  • Kras, Istria County, a village near Buzet, Croatia
  • Kras, Krk Island, a village near Dobrinj, Primorje-Gorski Kotar County, Croatia

  • KRAS

    GTPase KRas also known as V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog and KRAS, is a protein that in humans is encoded by the KRAS gene.

    The protein product of the normal KRAS gene performs an essential function in normal tissue signaling, and the mutation of a KRAS gene is an essential step in the development of many cancers. Like other members of the ras subfamily, the KRAS protein is a GTPase and is an early player in many signal transduction pathways. KRAS is usually tethered to cell membranes because of the presence of an isoprene group on its C-terminus. There are two protein products of the KRAS gene in mammalian cells that result from the use of alternative exon 4 (exon 4A and 4B respectively): K-Ras4A and K-Ras4B, these proteins have different structure in their C-terminal region and utilise different mechanisms to localize to cellular membranes including plasma membrane.

    Function

    KRAS acts as a molecular on/off switch. Once it is turned on, it recruits and activates proteins necessary for the propagation of growth factor and other receptors' signal such as c-Raf and PI 3-kinase. KRAS upregulates the GLUT1 glucose transporter, thereby contributing to the Warburg effect in cancer cells. KRAS binds to GTP in the active state and possesses an intrinsic enzymatic activity which cleaves the terminal phosphate of the nucleotide converting it to GDP. Upon conversion of GTP to GDP, KRAS is turned off. The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase-activating protein (GAP) class, for example RasGAP. In turn KRAS can bind to proteins of the Guanine Nucleotide Exchange Factor (GEF) class, for example SOS1, which forces the release of bound nucleotide (GDP). Subsequently, KRAS binds GTP present in the cytosol and the GEF is released from ras-GTP.

    Radio Stations - Kras_Stadion

    RADIO STATION
    GENRE
    LOCATION
    Wereld FM Varied Netherlands
    Limburg Express Varied Netherlands
    M-FM Rock,Pop Netherlands
    Randstadradio Classic Rock,Top 40,Hip Hop Netherlands
    Dream Stream Radio Pop,Dance Netherlands
    Radio 10 Gold 80s Hits 80s Netherlands
    Radio M Utrecht News Netherlands
    Hofstreek Omroep Varied Netherlands
    Jupiter Radio Varied Netherlands
    RGL FM Public Netherlands
    Pro FM Dance,Electronica Netherlands
    JV Radio (Radio 058) Pop Netherlands
    PartyFriends FM Top 40 Netherlands
    SRC FM Varied Netherlands
    Pidi Radio Varied Netherlands
    Keizerstad Hits Pop Netherlands
    Factory Station Varied Netherlands
    Exxact FM Varied Netherlands
    Concertzender Nieuwe Muziek Classical Netherlands
    Golfbreker News Netherlands
    Vechtdal FM Varied Netherlands
    AVRO 60ies Steenen Tijdperk 60s Netherlands
    RTV Zilverstad Public Netherlands
    Concertzender Live Varied Netherlands
    LOG (Lokale Omroep Goirle) Public Netherlands
    Intergalactic Rap Attack! Hip Hop,Rap Netherlands
    Radio DRP: House Electronica Netherlands
    Omroep Gelderland Unknown Netherlands
    Radio NL Varied Netherlands
    DFM RTV INT Varied,Contemporary,Experimental Netherlands
    All4You Hitradio 90s,Pop,Dance,Top 40 Netherlands
    Radio Acacia Folk Netherlands
    Concertzender Jazz Jazz Netherlands
    RTV Oost Alles Plat Varied Netherlands
    Maasland FM Varied Netherlands
    Muziekteam Varied Netherlands
    Radio Castricum 105 Varied Netherlands
    Intergalactic Classix Adult Contemporary,Electronica Netherlands
    Soul Movement R&B Netherlands
    Radio Hit NL Varied Netherlands
    Earthbeat Radio Ambient,New Age Netherlands
    Team FM Drenthe en Groningen Folk Netherlands
    Klokradio live Varied Netherlands
    Nova Classic Rock Classic Rock Netherlands
    Radio Carpe Diem Varied Netherlands
    Concertzender Oude Muziek Classical Netherlands
    Kontakt FM News Talk Netherlands
    Flamingo Radio Varied Netherlands
    EHAM - Amsterdam (Schiphol) Varied Netherlands
    RTV Parkstad Radio Public Netherlands
    PUR Radio Krijtland Public Netherlands

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