Eugene V. Koonin (Russian: Евге́ний Ви́кторович Ку́нин) (born October 26, 1956) is a Russian-American biologist and Senior Investigator at the National Center for Biotechnology Information (NCBI). He is a recognised expert in the field of evolutionary and computational biology.
Koonin gained a Master of Science in 1978 and a PhD in 1983 in molecular biology, both from the Department of Biology at Moscow State University. His PhD thesis, titled "Multienzyme organization of encephalomyocarditis virus replication complexes", was supervised by Vadim I. Agol.
From 1985-1991, Koonin worked as a research scientist in computational biology in the Institutes of Poliomyelitis and Microbiology at the USSR Academy of Medical Sciences, studying virus biochemistry and bacterial genetics. In 1991, Koonin moved to the NCBI, where he has held a Senior Investigator position since 1996.
Koonin's principal research goals include the comparative analysis of sequenced genomes and automatic methods for genome-scale annotation of gene functions. He also researches in the application of comparative genomics for phylogenetic analysis, reconstruction of ancestral life forms and building large-scale evolutionary scenarios, as well as mathematical modeling of genome evolution. Koonin's research also investigates computational study of the major transitions in the evolution of life (such as the origin of eukaryotes), the evolution of eukaryotic signaling and developmental pathways from the comparative-genomic perspective.
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