KLK7
Kallikrein-related peptidase 7 (KLK7) is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme (SCCE). It was later identified as the seventh member of the human kallikrein family, which includes fifteen homologous serine proteases located on chromosome 19q13.
Gene
Alternative splicing of the KLK7 gene results in two transcript variants encoding the same protein.
Function
KLK7 is secreted as an inactive zymogen in the stratum granulosum layer of the epidermis, requiring proteolytic cleavage of the short N-terminal pro-region to liberate activated enzyme. This may be performed by KLK5 or matriptase, which are in vitro activators of KLK7.
Once active, KLK7 is able to cleave desmocollin and corneodesmosin. These proteins constitute the extracellular component of corneodesmosomes, intercellular cohesive structures which link the intermediate filaments of adjacent cells in the stratum corneum. Proteolysis of corneodesmosomes is required for desquamation, the shedding of corneocytes from the outer layer of the epidermis. This indicates a role for KLK7 in maintaining skin homeostasis.
Podcasts:
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by Kelly Keagy
Everything I Need In A Woman
by: Kelly KeagyThis is a story
As old as time
About losing love
And finding love again.
Givin’ up on everything
losing faith that tryin
Would bring me home,
Take me home once again.
Never stop believin’ in a
Power strong enough
To take me back
And make me feel
The magic of a touch.
You’re everything I need in a woman
You’re what made me believe in love again
You’re where I want to be with a woman
But it’s gonna take a real woman
To make me believe in love again
I wanna believe in love again.
Without even knowin’,
You can read my mind
You sang right through
The hardness of my heart.
Could it be that you’ve been through
Everything I’ve been through?
And now we’ve both found our way in the dark
I was always reachin’
But it was just beyond my touch
I had everything I wanted
But it was never quite enough
You’re everything I need in a woman
You’re what made me believe in love again
You’re where I want to be with a woman
But it’s gonna take a real woman
To make me believe in love again
I wanna believe in love again.
Now gone are the dark days that kept me from the night
Now I know the way my life’s supposed to be
When we’re apart you’re always in my heart
There’s a part of you that’s still a part of me
You’re everything I need in a woman
You’re what made me believe in love
You’re everything I need in a woman
You’re what made me believe in love
You’re everything that’s meant to be in a woman
You’re everything I need in a woman
But it’s gonna take a real woman
To make me believe in love again