Kir6.2
Kir6.2 is a major subunit of the ATP-sensitive K+ channel, an inward-rectifier potassium ion channel. The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism.
Structure
It is an integral membrane protein. The protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor (SUR) to constitute the ATP-sensitive K+ channel.
Pathology
Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM).
See also
References
Further reading
External links
Podcasts:
Car 54
by: Suburban LegendsSometimes when I'm alone I always get this way,
I just think about how everyone is lame.
Jealousy and greed run rampant every day,
I think I'll forget this stuff, I'll go and run away.
Gohan
Where are you?
Gohan
Where are you?
Just run away.
What really gets to me is this mass stupidity,
Oh well I forgot I live in the land of the free.
Just remember not to hate nor to turn to apathy,
Than maybe we can change this really messed up society.
Gohan
Where are you?
Gohan
Where are you?
Just run away.
Every night around eight thirty my parents yell at me,
They say I'm stupid 'cause I watch my MTV.
When I looked in the miror I swear I saw someone else,
So I cut my hair, got a job and joined a really cool band.
Gohan
Where are you?
Gohan
Where are you?
Just run away.