BNC

BNC may refer to:

Technology

Organizations

BNC210

BNC210 (also known as IW-4123 during its time licensed to Ironwood Pharmaceuticals) is an anxiolytic drug that acts via negative allosteric modulation of the α₇-nicotinic acetylcholine receptor, by Bionomics Limited. It demonstrates clinically significant anxiety reduction in both animal models and in Phase I trials.

It appears to be devoid of significant sedation or memory-impairing side effects, as well as lacking addictive potential in rat discriminatory models.

Phase I trials have shown no serious side effects.

Bionomics previously licensed it to Ironwood Pharmaceuticals in January 2012, where it was known as IW-2143. In December 2012, IW-2143 begun undergoing phase I clinical trials in the United States, but in November 2014, was released back to Bionomics in a mutual agreement. Bionomics will now continue development and clinical testing, with Ironwood receiving a royalty for their work done.

As of April 2015, BNC210 is in phase II clinical trials.

See also

Zinc finger protein basonuclin-2

Zinc finger protein basonuclin-2 is a protein that in humans is encoded by the BNC2 gene. BCN2 has recently been shown to influence skin pigmentation levels in Europeans. Genomic region spanning the BCN2 gene has 60% Neanderthal DNA sequence.

References

Further reading

Kela

Kela or KELA may refer to:

Kela (Finnish institution)

Kela, abbr. from Finnish: Kansaneläkelaitos, Swedish: Folkpensionsanstalten (FPA), is a Finnish government agency in charge of settling benefits under national social security programs. Kela was founded in 1937 to handle retirement pay. In the 1980s and 1990s, its role was expanded to handle other fields like child benefits, unemployment benefits, sickness benefits, health insurance and student benefits.

Kela is funded directly from taxation. Coverage under the scheme is given to all permanent residents of Finland. Kansaneläkelaitos/Folkpensionsanstalten literally means "People's Pension Institute", reflecting its original function as the national provider of retirement benefits.

In May 2008, a Kela e-service apparently disclosed confidential medical insurance information to the wrong client, and subsequently took that service offline.

References

External links

Kela (tribe)

The Kela are a Muslim community found in the state of West Bengal in India. They are also known as Kharia Muslim.

Origin

The Kela are a hunting and gathering community found in the district of Midnapore. They were traditionally involved in the catching of snakes, toads and birds, a profession considered derogatory by neighbouring communities. The word Kela has been derived from the word kala, which means unclean in Bengali. They are also known as Kharia Muslims, as they are said to be converts from the Kharia caste, and prefer to be known as Kharia.

Present circumstances

The Kela have now entirely given up their traditional occupation, and the majority are now marginal farmers or sharecroppers. A significant minority are also involved in repairing locks, and now suitcases. The community is strictly endogamous, and marry close kin. They live in multi-caste villages, but occupy their distinct quarters, known as paras. The community are Sunni Muslims and speak Bengali language.

See also