KLRC2

NKG2-C type II integral membrane protein is a protein that in humans is encoded by the KLRC2 gene.

Function

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.

Interactions

KLRC2 has been shown to interact with KLRD1. The binding of this CD94/NKG2C heterodimer to its cellular ligand HLA-E has been shown to drive the expansion of a subset of Natural Killer (NK) cells in response to viral infections.

KLRC4

NKG2-F type II integral membrane protein is a protein that in humans is encoded by the KLRC4 gene.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.

References

KLRC

KLRC is a non-commercial Contemporary Christian music radio station based in Siloam Springs, Arkansas broadcasting on 90.9 FM in Northwest Arkansas and northeast Oklahoma.

It is also heard on 101.1 in Siloam Springs, AR, 99.1 FM in Bentonville, and at 103.5 FM in Springdale. The Gospel Music Association (GMA) has named KLRC as the GMA/Christian Music Broadcasters (CMB) Small Market Radio Station of the Year four times: in 2001, 2002, 2006, and 2008. The National Association of Broadcasters (NAB) named KLRC the Marconi Award winner for Religious Station of the Year in 2013.

Station history

KLRC began in late August 1983 as a 100 watt station serving only the John Brown University (JBU) campus and the immediate community. Located at 90.3 FM, the station was housed in the Cathedral of the Ozarks on the JBU campus. Its primary purpose was to serve as a training ground for JBU broadcasting students.

In the fall of 1988, the U.S. Federal Communications Commission (FCC) approved a power increase to 3,100 watts effective radiated power. With the higher power, the FCC also changed the frequency of KLRC from 90.3 to 101.1 FM.