WWC1

Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.

A single nucleotide polymorphism (rs17070145) in the gene has been association with human memory performance in one 2006 study. No significant support for association with memory was found in a study with 584 subjects. However it was replicated in a smaller study of the elderly. A subsequent study in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.

Studies have also begun to investigate the role of KIBRA in Alzheimer's disease.

Interactions

KIBRA has at least 10 interaction partners, including synaptopodin, PKCζ and Dendrin, most of which modify synaptic plasticity. For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.KIBRA has been shown to interact with Protein kinase Mζ.

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