KH domain

The K Homology (KH) domain is a protein domain that was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety of nucleic acid-binding proteins. The KH domain binds RNA, and can function in RNA recognition. It is found in multiple copies in several proteins, where they can function cooperatively or independently. For example, in the AU-rich element RNA-binding protein KSRP, which has 4 KH domains, KH domains 3 and 4 behave as independent binding modules to interact with different regions of the AU-rich RNA targets. The solution structure of the first KH domain of FMR1 and of the C-terminal KH domain of hnRNP K determined by nuclear magnetic resonance (NMR) revealed a beta-alpha-alpha-beta-beta-alpha structure. Autoantibodies to NOVA1, a KH domain protein, cause paraneoplastic opsoclonus ataxia. The KH domain is found at the N-terminus of the ribosomal protein S3. This domain is unusual in that it has a different fold compared to the normal KH domain.

Domain

Domain may refer to:

Information technology

Domain wall

A domain wall is a type of topological soliton that occurs whenever a discrete symmetry is spontaneously broken. Domain walls also sometimes called kinks in analogy with closely related kink solution of the sine-Gordon model. Unstable domain walls can also appear if spontaneously broken discrete symmetry is approximate and there is the metastable vacuum.

A domain (hyper volume) is extended in three spatial dimensions and one time dimension. A domain wall is the boundary between two neighboring domains. Thus a domain wall is extended in two spatial dimensions and one time dimension.

Important examples are:

Besides these important cases similar solitons appear in wide spectrum of the models. Here are other examples:

Domain (band)

Domain is a German power metal band.

History

1986–1992

Domain first impressed fans of melodic metal back in the 1980s with their first works, "Lost In The City" (still under the old band name Kingdom), "Before The Storm" and "Crack in The Wall", as well as with their hit songs such as 'Lost In The City' and ‚ 'I Don’t Wanna Die'. Single "Heart Of Stone was a title song of german mini-serial "Bastard".

2000–2006

But it was their next albums, "One Million Lightyears From Home" (2001), "The Artefact" (2002) and "The Sixth Dimension" (2003) as well as a successful tour with the rock legends, Glenn Hughes and Joe Lynn Turner (HTP) that secured the quintet a place in the European Melodic Metal scene. With a harder edged sound, Domain still had a good following. And that was when the career of the guitarist Axel "Ironfinger" Ritt (Grave Digger), ex-vocalist Carsten Lizard Schulz (Evidence One et al.), and the long-term band mates keyboarder Erdmann Lange, ex-bass player Jochen Mayer (Boysvoice, Demon Drive, Casanova) and the ex-drummer Stefan Köllner really began…