KDM

KDM or Kdm may refer to:

KDM1A

Lysine-specific histone demethylase 1A (KDM1A) also known as lysine (K)-specific demethylase 1A (LSD1) is a protein in humans that is encoded by the KDM1A gene. LSD1 is a flavin-dependent monoamine oxidase, which can demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9 (H3K4 and H3K9). This enzyme can have roles critical in embryogenesis and tissue-specific differentiation, as well as oocyte growth. KDM1A was the first histone demethylase to be discovered though more than 30 have been described.

Structure

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase.

Function

LSD1 (lysine-specific demethylase 1), also known as KDM1, is the first of several protein lysine demethylases discovered. Through a FAD-dependent oxidative reaction, LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. It's now known LSD1 complex mediates a coordinated histone modification switch through enzymatic activities as well as histone modification readers in the complex.

Gorgon (missile family)

The Gorgon was an air-to-air missile powered by a turbojet engine and equipped with radio controls and a homing device.

It was developed by the U.S. during World War II, was later expanded into a more general program including turbojet, ramjet, pulsejet, and rocket power. Straight wing, swept wing, and canard (tail first) air frames were investigated and visual, television, heat-homing, and three types of radar guidance were looked at for use as possible air-to-air, air-to-surface and surface-to-surface guided missiles and as target drones.

The final development of the series, the ASM-N-5 Gorgon V, was to be an unpowered chemical weapons dispenser.

Variants

Data from:

References

External links