KCNC-TV

KCNC-TV, virtual channel 4 (UHF digital channel 35), is a CBS owned-and-operated television station located in Denver, Colorado, United States. The station is owned by the CBS Television Stations subsidiary of CBS Corporation. KCNC maintains studio facilities located on Lincoln Street (between East 10th and 11th Avenues) in downtown Denver, and its transmitter is based on Lookout Mountain, near Golden.

History

As an NBC affiliate

The station first signed on the air on December 24, 1952 as KOA-TV. Founded by Metropolitan Broadcasting (partly owned by famed comedian Bob Hope), owners of KOA radio (850 AM and 103.5 FM, now KRFX), channel 4 immediately assumed the NBC affiliation from KBTV (channel 9, now KUSA), due to KOA radio's longtime affiliation with and ownership by the NBC Red Network.

In 1965, KOA-TV began carrying most of NBC's American Football League game telecasts as the network obtained the league's broadcast television rights (with play-by-play announcing duties handled by Curt Gowdy); however, Denver Broncos home games aired by the network had to be blacked out due to the team's inability to sell out tickets to the games (NFL blackout rules in effect at the time required teams to sell all tickets for home games in order to allow them to be broadcast in the team's primary market; the league has since lowered the designated sales threshold to allow home game broadcasts to 75% of all tickets). In 1967, KOA-TV ran an award-winning documentary The Acid Test, LSD; hosted by news editor Bob Palmer, the film took five months to produce with more than 5,000 feet of film shot. Photographers involved included Bill Baker, Medill Barnes, Jerry Curran, Sam Houston and Barry Trader.

KCNC3

Potassium voltage-gated channel, Shaw-related subfamily, member 3 also known as KCNC3 or K_v3.3 is a protein that in humans is encoded by the KCNC3.

Function

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.

Clinical significance

KCNC3 is associated with spinocerebellar ataxia type 13.

See also

References

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

KCNC2

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).

Expression pattern

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.

Physiological role

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation. Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.

Pharmacological properties

K_v3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC₅₀ values are 0.1 mM for both of the drugs). This can be useful in identifying native channels.