JWH-176
Systematic (IUPAC) name
1-([(1E)-3-pentylinden-1-ylidine]methyl)naphthalene
Clinical data
Pregnancy cat.  ?
Legal status Legal
Identifiers
ATC code  ?
Chemical data
Formula C25H24 
Mol. mass 324.457 g/mol
SMILES eMolecules & PubChem
 YesY (what is this?)  (verify)

JWH-176 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 26.0nM, making it more potent than THC itself,[1] however JWH-176 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor.[2] It was discovered by, and named after, Dr. John W. Huffman.

See also [link]

References [link]

  1. ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
  2. ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X
Stub icon This cannabinoid related article is a stub. You can help Wikipedia by expanding it.

https://wn.com/JWH-176

JWH-048

JWH-048 is a selective cannabinoid ligand, with a bindining affinity of Ki = 0.5 ± 0.1 nM for the CB2 subtype, and more than 22 times selectivity over the CB1.

See also

  • JWH-015
  • JWH-018
  • JWH-019
  • JWH-073

    • References

  • ↑ Aung MM, Griffin G, Huffman JW, Wu M-J, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540.
    • Read more
    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/JWH-048

    JWH-147

    JWH-147 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 11.0nM at CB1 vs 7.1nM at CB2. It was discovered and named after Dr. John W. Huffman. JWH-147 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.

    See also

  • JWH-030
  • JWH-307

    • References

  • ↑ Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters 2006; 16:5432-5435.
  • ↑ Swedish Code of Statutes Regulation (2010:1086).
  • ↑ Swedish Code of Statutes Regulation (2010:1086). (pdf)


    • Read more
    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/JWH-147

    JWH-398

    JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3nM and 2.8nM at CB2. It was identified by the EMCDDA as an ingredient in three separate "herbal incense" products purchased from online shops between February to June 2009. It was discovered by, and named after, Dr. John W. Huffman.

    See also

  • JWH-122
  • JWH-424

    • References


    Read more
    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/JWH-398

    Podcasts:

    Email this Page Play all in Full Screen Show More Related Videos
    PLAYLIST TIME:

    Love Is Just A Game

    by: Joe

    Love is just a game
    Oooh ooh ooh ooh yeah yeah yeah (telling you)
    Baby...
    You cant keep doing this shit...
    Oh oh, love is just a game...
    Oh, listen babe...
    Quit playing around, like it's a game,
    You tell me to go, you tell me to stay,
    Living with you is emotional,
    Roller coaster ride, like you're just gone and hide,
    Crossing the T's, and dotting the I's,
    Trying to make it work but you won't let me,
    It's like you're fighting with your self,
    But baby I can tell, that you really don't wanna leave,
    Love is a game for you, I see, but it means a lot more to me,
    To ride it out when the going gets rough,
    Then she closed the first real love,
    Can't keep playing around with me,
    If you really don't want me to leave,
    Cos if love is a game, then I don't wanna play,
    Cos there's someone out there for me,
    Love is just a game...
    Heard you were on the phone just the other day,
    Talking to your girls, telling you that I'm leaving,
    If you didn't mean it then why did you say it,
    Cos love it ain't a game to me,
    I'm packing my bags here I go again,
    Wanna kick me out, ok, well I'm leaving,
    And with those shorties came, so baby tell me
    What's it gonna be,
    I'm tired of all the fussing, and the fighting
    We can't keep, just going on this way
    So tired babe and angry,
    You hurting me over and over again,
    You making me wanna leave,
    U don't understand just what you're doing to me




    ×
    ×
    ×
    ×