Joseph de Guignes (19 October 1721 – 19 March 1800) was a French orientalist, sinologist and Turkologist born at Pontoise, the son of Jean Louis de Guignes and Françoise Vaillant. He died at Paris.
He succeeded Étienne Fourmont at the Royal Library as secretary interpreter of the Eastern languages. His Mémoire historique sur l'origine des Huns et des Turcs, published in 1748, earned him admission to the Royal Society of London in 1752, and he became an associate of the French Academy of Inscriptions in 1754. There soon followed the three-volume work Histoire générale des Huns, des Mongoles, des Turcs et des autres Tartares occidentaux (1756–1758). In 1757, he was appointed to the chair of Syriac at the Collège de France.
He originated the proposal that the Huns who attacked the Roman Empire were the same people as the Xiongnu mentioned in Chinese records. This view was popularised by his contemporary Edward Gibbon in Gibbon's work Decline And Fall Of The Roman Empire. The proposal has been strenuously debated by central Asianists including Maenchen-Helfen, Henning, Bailey, and de la Vaissière.
Guignes is a commune in the Seine-et-Marne département in the Île-de-France region in north-central France.
Inhabitants are called Guignois.