Joan Orpí i del Pou, also Juan Orpín or Juan Urpín (1593 in Piera – 1 July 1645 in Barcelona, Venezuela) was a Spanish conquistador, known for founding New Barcelona in Venezuela, and for founding the short-lived Province of New Catalonia (1633–1654).
In 1623 he journeyed to Araya. In 1624 the Governor of New Andalusia Province, Diego de Arroyo Daza, named Orpí Lieutenant General of the province, a position he held until 1627/8. That year the Real Audiencia of Santo Domingo recognised the law degree he had obtained in Barcelona, and he began acting as a legal representative of the Audiencia in Caracas.
In 1631 he moved to Santo Domingo, where the difficulty of communication between the Venezuela Province (Caracas) and the New Andalusia Province (Cumaná) was a matter of some concern. He agreed to launch an expedition to secure the territory between the Unare River and the Neverí River, inhabited by the Cumanagotos, and was granted the royal privilege to do so, despite opposition from others. His expedition began in 1632 but had to be called off when the privilege was revoked, and he had to plead a case to the Audiencia and to the Council of the Indies to regain it, which he was able to do in 1636.
ORP may refer to:
Lactisole is a carboxylic acid salt. Like gymnemic acid, it is a sweet inhibitor or taste modifier.
Chemically, lactisole is the sodium salt of 2-(4-methoxyphenoxy)propionic acid.
This acid has been isolated from roasted Colombian Arabica Coffee beans.
At concentrations of 100–150 parts per million in food, lactisole largely suppresses the ability to perceive sweet tastes, both from sugar and from artificial sweeteners such as aspartame. A 12% sucrose solution was perceived like a 4% sucrose solution when lactisole was added. However, it is significantly less efficient than gymnemic acid with acesulfame potassium, sucrose, glucose and sodium saccharin. Research found also that it has no effect on the perception of bitterness, sourness and saltiness. According to a recent study, lactisole acts on a sweet taste receptor heteromer of the TAS1R3 sweet protein receptor in humans, but not on its rodent counterpart.