Hendler's research interests are in the semantic web and artificial intelligence. Hendler held a longstanding position as professor at the University of Maryland where he was the Director of the Joint Institute for Knowledge Discovery and held joint appointments in the Department of Computer Science, the Institute for Advanced Computer Studies and the Institute for Systems Research. Hendler was the Director for Semantic Web and Agent Technology at the Maryland Information and Network Dynamics Laboratory. He is a Fellow of the American Association for Artificial Intelligence, the British Computer Society, the Institute of Electrical and Electronics Engineers and the AAAS.