JWH-133 is a potent selective CB2 receptor agonist with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors. It was discovered by and named after, John W. Huffman.
JWH-133, alongside WIN 55,212-2 and HU-210, is responsible for preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers . This anti-inflammatory action is induced through agonist action at cannabinoid receptors, which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.
It may be linked with anti-cancer properties, according to pre-trial data from a 2010 study in Madrid.
The substance commonly referred to as "JWH-133" is not a scheduled substance in the U.S, except in Alabama. Low abuse potential makes it less likely for regulation relative to its sister drugs such as JWH-018, as JWH-133 is selective for the non-psychoactive CB2 receptor and thus lacks significant psychoactive effects.
Love is just a game
Oooh ooh ooh ooh yeah yeah yeah (telling you)
Baby...
You cant keep doing this shit...
Oh oh, love is just a game...
Oh, listen babe...
Quit playing around, like it's a game,
You tell me to go, you tell me to stay,
Living with you is emotional,
Roller coaster ride, like you're just gone and hide,
Crossing the T's, and dotting the I's,
Trying to make it work but you won't let me,
It's like you're fighting with your self,
But baby I can tell, that you really don't wanna leave,
Love is a game for you, I see, but it means a lot more to me,
To ride it out when the going gets rough,
Then she closed the first real love,
Can't keep playing around with me,
If you really don't want me to leave,
Cos if love is a game, then I don't wanna play,
Cos there's someone out there for me,
Love is just a game...
Heard you were on the phone just the other day,
Talking to your girls, telling you that I'm leaving,
If you didn't mean it then why did you say it,
Cos love it ain't a game to me,
I'm packing my bags here I go again,
Wanna kick me out, ok, well I'm leaving,
And with those shorties came, so baby tell me
What's it gonna be,
I'm tired of all the fussing, and the fighting
We can't keep, just going on this way
So tired babe and angry,
You hurting me over and over again,
You making me wanna leave,
U don't understand just what you're doing to me