JWH-015 is a chemical from the naphthoylindole family that acts as a subtype-selective cannabinoid agonist. Its affinity for CB2 receptors is 13.8 nM, while its affinity for CB1 is 383 nM, meaning that it binds almost 28x more strongly to CB2 than CB1 However it still displays some CB1 activity, and in some model systems can be very potent and efficacious at activating CB1 receptors, and therefore it is not as selective as newer drugs such as JWH-133. It has been shown to possess immunomodulatory effects, and CB2 agonists may be useful in the treatment of pain and inflammation. It was discovered and named after Dr. John W. Huffman.
JWH-015 has been shown in vitro to be metabolised primarily by hydroxylation and N-dealkylation, and also by epoxidation of the naphthalene ring, similar to the metabolic pathways seen for other aminoalkylindole cannabinoids such as WIN 55,212-2.Epoxidation of polycyclic aromatic hydrocarbons (see for example benzo(a)pyrene toxicity) can produce carcinogenic metabolites, although there is no evidence to show that JWH-015 or other aminoalkylindole cannabinoids are actually carcinogenic in vivo. A study published in the British Journal of Cancer shows that JWH-015 may signal certain cancers to shrink through a process called apoptosis.
Love is just a game
Oooh ooh ooh ooh yeah yeah yeah (telling you)
Baby...
You cant keep doing this shit...
Oh oh, love is just a game...
Oh, listen babe...
Quit playing around, like it's a game,
You tell me to go, you tell me to stay,
Living with you is emotional,
Roller coaster ride, like you're just gone and hide,
Crossing the T's, and dotting the I's,
Trying to make it work but you won't let me,
It's like you're fighting with your self,
But baby I can tell, that you really don't wanna leave,
Love is a game for you, I see, but it means a lot more to me,
To ride it out when the going gets rough,
Then she closed the first real love,
Can't keep playing around with me,
If you really don't want me to leave,
Cos if love is a game, then I don't wanna play,
Cos there's someone out there for me,
Love is just a game...
Heard you were on the phone just the other day,
Talking to your girls, telling you that I'm leaving,
If you didn't mean it then why did you say it,
Cos love it ain't a game to me,
I'm packing my bags here I go again,
Wanna kick me out, ok, well I'm leaving,
And with those shorties came, so baby tell me
What's it gonna be,
I'm tired of all the fussing, and the fighting
We can't keep, just going on this way
So tired babe and angry,
You hurting me over and over again,
You making me wanna leave,
U don't understand just what you're doing to me