JWH-007 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It was the most active of the first group of N-alkyl naphoylindoles discovered by the team led by John W Huffman, several years after the family was initially described with the discovery of the N-morpholinylethyl compounds pravadoline (WIN 48,098), WIN 55,225 (JWH-200) and WIN 55,212-2 by the Sterling Winthrop group. Several other N-alkyl substituents were found to be active by Huffman's team including the n-butyl, n-hexyl, 2-heptyl and cyclohexylethyl groups, but it was subsequently determined that the 2-methyl group on the indole ring is not required for CB1 binding, and tends to increase affinity for CB2 instead. Consequently, the 2-desmethyl derivative of JWH-007, JWH-018 has slightly higher binding affinity for CB1, with an optimum binding of 9.00nM at CB1 and 2.94nM at CB2, and JWH-007 displayed optimum binding of 9.50nM at CB1 and 2.94nM at CB2.
Love is just a game
Oooh ooh ooh ooh yeah yeah yeah (telling you)
Baby...
You cant keep doing this shit...
Oh oh, love is just a game...
Oh, listen babe...
Quit playing around, like it's a game,
You tell me to go, you tell me to stay,
Living with you is emotional,
Roller coaster ride, like you're just gone and hide,
Crossing the T's, and dotting the I's,
Trying to make it work but you won't let me,
It's like you're fighting with your self,
But baby I can tell, that you really don't wanna leave,
Love is a game for you, I see, but it means a lot more to me,
To ride it out when the going gets rough,
Then she closed the first real love,
Can't keep playing around with me,
If you really don't want me to leave,
Cos if love is a game, then I don't wanna play,
Cos there's someone out there for me,
Love is just a game...
Heard you were on the phone just the other day,
Talking to your girls, telling you that I'm leaving,
If you didn't mean it then why did you say it,
Cos love it ain't a game to me,
I'm packing my bags here I go again,
Wanna kick me out, ok, well I'm leaving,
And with those shorties came, so baby tell me
What's it gonna be,
I'm tired of all the fussing, and the fighting
We can't keep, just going on this way
So tired babe and angry,
You hurting me over and over again,
You making me wanna leave,
U don't understand just what you're doing to me