JUNQ and IPOD

JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes.

Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of misfolded proteins in inclusion bodies. For many years, protein aggregation was considered a random process by which misfolded proteins stick to each other to form inclusions (imagine a bundle of hairs haphazardly piling up in a corner of a room). Moreover, protein aggregates were thought to be toxic agents and the cause for neuronal dysfunction and death. However, recent studies, using advanced methods (i.e. Fluorescence microscopy), show that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process:

List of iPod models

The Apple iPod line has been upgraded many times, and each significant revision is called a "generation". Only the most recent generation and refurbished units of previous generations of the iPod line are available from Apple for each model (classic, nano, shuffle, touch). Each new generation usually has more features and refinements while typically being physically smaller and lighter than its predecessor, while usually (but not always) retaining the older model's price tag. Notable changes include the touch-sensitive click wheel replacing the mechanical scroll wheel, use of color displays, and flash memory replacing hard disks.

Models

The software bundled with the first generation iPod was Macintosh-only, so Windows users had to use third-party updates like ephPod or XPlay to manage their music. When Apple introduced the second generation of iPods in July 2002, they sold two versions, one that included iTunes for Macintosh users and another that included Musicmatch Jukebox for Windows users. In October 2003, Apple released the Windows version of iTunes, and started selling iPods that included both Macintosh and Windows versions of iTunes so that they could be used with either platform. Current iPods no longer ship with iTunes, which must be downloaded from Apple's website.

IPOD (disambiguation)

The iPod is a portable media player. (not to be confused with iPad)

IPOD may also refer to: