JAM2
Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322 (cluster of differentiation 322).
Function
Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
It is purported to promote lymphocyte transendothelial migration. It might also be involved with endothelial cell polarity, by associating to cell polarity protein PAR-3, together with JAM3.
Interactions
JAM2 has been shown to interact with PARD3.
It also interacts with α4β1.
References
Further reading
Podcasts:
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by M.I.A.
Jimmy
by: M.I.A.Jimmy, Jimmy
Come back Jimmy
When you go Rwanda Congo
Take me on ya genocide tour
Take me on a truck to Darfur
Take me where you would go
Got static on ya satellite phone
Got to get you safe at home
Got to get you some where warm
So you get me all alone
Jimmy Aaja
Jimmy Aaja
Jimmy Aaja
Time and time and time and time again
You keep pushing that button but I don't know what your sayin
You hit me on AIM tryin' flip me on some game
Are you coming are you going are you leaving are you staying
You told me that your busy
Your loving makes me crazy
I know that you hear me
Start acting like you want me
You told me that your busy
Your loving makes me crazy
I know you can hear me
Start acting like you want me
Jimmy Aaja
Jimmy Aaja
Jimmy Aaja
Time and time and time and time again
You keep pushing me, what you sayin
You hit me on AIM, flip me on some game
But I still don't know what you're sayin'
You told me that your busy
Your loving makes me crazy
I know that you hear me
Start acting like you want me
You told me that your busy
Your loving makes me crazy
I know you can hear me
Start acting like you want me
Jimmy Aaja
Jimmy Aaja