Janus kinase 2
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). JAK2 signaling is activated downstream from the prolactin receptor.
The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) and the presence of up to seven JAK homology domains (JH1-JH7). Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. An interesting note is that only one of these carboxy-terminal JH domains retains its function whilst the other, due to lacking important amino acids for kinase functionality, does not work; it is therefore termed as the pseudokinase domain.
Podcasts:
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by Jake Hook
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by Jake Hook
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by Jack & Joy
Reform
by: Jake HookYou hit the ground 3000 miles too fast and you break
You fall into rivers of tears and you ache
And you hold onto the brink and you fall, you sink, it laughs and you think
I’m ok!
Well if I’m ok
Why do I break?
And If I fall will I reform?
And If I fall will I reform?
So you pick yourself up and they laugh
And you dust yourself down to reveal scars
and you hold on to the hope that wings will come to fix you
But it’s too late
And If I’m Ok?
Why does she break?
If I fall will I reform?
If I fall will I reform?
3000 miles and no one saves you
Please don’t drown in your own tears
And I will try to save you
If you’d only try and save me
When you fall, you will reform
When you fall