Integrin, alpha 6
Identifiers
Symbols ITGA6; CD49f; ITGA6B; VLA-6
External IDs OMIM: 147556 MGI: 96605 HomoloGene: 20091 ChEMBL: 3716 GeneCards: ITGA6 Gene
RNA expression pattern
PBB GE ITGA6 201656 at tn.png
PBB GE ITGA6 215177 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3655 16403
Ensembl ENSG00000091409 ENSMUSG00000027111
UniProt P23229 Q61739
RefSeq (mRNA) NM_000210.2 NM_008397.3
RefSeq (protein) NP_000201.2 NP_032423.2
Location (UCSC) Chr 2:
173.29 – 173.37 Mb		 Chr 2:
71.58 – 71.7 Mb
PubMed search [1] [2]
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Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[1]

Contents

Interactions [link]

ITGA6 has been shown to interact with TSPAN4[2] and GIPC1.[3]

See also [link]

References [link]

  1. ^ "Entrez Gene: ITGA6 integrin, alpha 6". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655. 
  2. ^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. DOI:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996. 
  3. ^ Tani, T T; Mercurio A M (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. (United States) 276 (39): 36535–42. DOI:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315. 

Further reading [link]

  • Lipscomb EA, Mercurio AM (2006). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression.". Cancer Metastasis Rev. 24 (3): 413–23. DOI:10.1007/s10555-005-5133-4. PMID 16258729. 

External links [link]
1-50
51-100
101-150
151-200
201-250
251-300
301-350
Alpha
A1 · A2 · A3 · A4 · A5 · A6 · A7 · A8 · A9 · A10 · A11 · AD · AE · AL · AM · AV · AX
Beta
B1 · B2 · B3 · B4 · B5 · B6 · B7 · B8
Dimers


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