Isakhel (Urdu: عِيسىٰ خيل) is a town of Mianwali District in the Punjab province of Pakistan. The town is the headquarters of Isakhel Tehsil, an administrative subdivision of the district.
Isakhel is an important town located in the west of Mianwali District. It is named after (Tarna to Isa Khan), a Niazi chief. Until November 1901 Isa Khel was the tehsil headquarters of Bannu District - however after the North-West Frontier Province was created from Punjab province, Bannu District was included in the NWFP without the Isakhel Tehsil. Isakhel became part of the newly formed Mianwali District of the Punjab. Isa Khel was under the rule of nawabs until the administrative powers were delegated to the town representatives among which the famous Bubly Khan is its main representative.
The town was founded about 1830 by Ahmad Khan, ancestor of the present Khans of Isa Khel, who were the acknowledged heads of the trans-Indus Niazai; and it takes its name from Isa Khan, a religious teacher and noble governor in Sher Shah Suri court. The municipality was created in 1875. The present Khans of Isakhel still reside there. The town's administrative power belongs to the Khans of Isakhel.