Iraq

Coordinates: 33°N 44°E / 33°N 44°E / 33; 44

Iraq (/ɪˈræk/, ⁱ/ɪˈrɑːk/, or /aɪˈræk/; Arabic: العراق‎ al-‘Irāq, Kurdish: Êraq), officially the Republic of Iraq (Arabic:  جمهورية العراق  Jumhūrīyat al-‘Irāq; Kurdish: كۆماری عێراق‎ Komar-i ‘Êraq), is a country in Western Asia. The country borders Turkey to the north, Iran to the east, Kuwait to the southeast, Saudi Arabia to the south, Jordan to the southwest, and Syria to the west. The southern part of Iraq is within the Arabian Peninsula. The capital, Baghdad, is in the centre of the country and its largest city. The largest ethnic groups in Iraq are Arabs and Kurds. Other ethnic groups include Assyrians, Turkmen, Shabakis, Yazidis, Armenians, Mandeans, Circassians, and Kawliya. Around 95% of the country's 36 million citizens are Shia or Sunni Muslims, with Christianity, Yarsan, Yezidism, and Mandeanism also present.

Iraq has a narrow section of coastline measuring 58 km (36 mi) on the northern Persian Gulf and its territory encompasses the Mesopotamian Alluvial Plain, the northwestern end of the Zagros mountain range, and the eastern part of the Syrian Desert. Two major rivers, the Tigris and Euphrates, run south through the centre of Iraq and flow into the Shatt al-Arab near the Persian Gulf. These rivers provide Iraq with significant amounts of fertile land.

Interleukin-1 receptor-associated kinase

Interleukin-1 receptor-associated kinase is a family of kinases.

Types include:

See also

References

IRAK4

IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAKM and Pelle. IRAK4 is unique compared to IRAK1, IRAK2 and IRAKM in that it functions upstream of the other IRAKs, but is more similar to Pelle in this trait. IRAK4 is important for its clinical applications.

Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.

History

The first IL-1 receptor-associated kinase (IRAK) was observed in 1994 through experiments with murine T helper cell lines D10N and EL-4. Two years later the first experimental member of this family of kinases, IRAK1, was cloned. In 2002, through database searches at the National Center for Biotechnology Information in an attempt to recognize novel members of the IRAK family, a human cDNA sequence which encoded a peptide sharing significant homology with IRAK1 was identified. This cDNA sequence was found to have five amino acid substitutions compared to IRAK1 and was termed IRAK4.