Introduction

Introduction, The Introduction, Intro, or The Intro may refer to:

Intro (Bravo Band album)

Intro (in Macedonian: Интро) is the debut album by the Macedonian male group Bravo Band. The album was released in October 2008 and it contains nine songs which are different by style.

Production history

The first single released from the album was "Lesno Ti E Tebe" ("It's easy for you") in 2006. With that song the band first promoted their self as a music group on the Macedonian festival Ohrid Fest. The song is work of Jovan Jovanov and Elvir Mekic which made their second single too called "Ne Bih Te Menjao" ("I wouldn't change you"). "Ne Bih Te Menjao" is a Serbian language song and it was the band's entry for Suncane Skale 2007. With this song they finished third in the first night with 63 points. The video for the song "Neka Patam" made by Dejan Milicevic was selected for best Macedonian video of 2008. In October all since then present songs they released on an album. The album is called Intro mainly for two reasons. The first one is the word intro which comes from the English word "introduction". It is just a metaphor for what they present in it, an introduction of their emotions which are in one way or another expressed in every song.

Ready to Die

Ready to Die is the debut studio album by American rapper The Notorious B.I.G.; it was released on September 13, 1994, by Bad Boy Records. The label's first release, the album features production by Bad Boy founder Sean "Puffy" Combs, Easy Mo Bee, Chucky Thompson, DJ Premier and Lord Finesse, among others. Recording for the album took place during 1993 to 1994 at The Hit Factory and D&D Studios in New York City. The partly autobiographical album tells the story of B.I.G.'s experiences as a young criminal. Ready to Die is his only studio album released during his lifetime, as he was murdered just days prior to the release of his second album, Life After Death (1997).

Ready to Die was released to critical acclaim and became a commercial success, achieving gold certification. In 1995, after the release, the album became a certified double platinum by the Recording Industry Association of America (RIAA), and the album has reached a certified quadruple platinum with sales. It was significant for revitalizing the east coast hip hop scene, amid West Coast hip hop's commercial dominance. The album's second single, "Big Poppa", was nominated for a Grammy Award for Best Rap Solo Performance at the 1996 Grammy Awards. Ready to Die has been regarded by many music critics as one of the greatest hip-hop albums of all time. In 2003, it was ranked number 133 on Rolling Stone magazine's list of the 500 greatest albums of all time, making it the third highest hip hop album on the list after It Takes a Nation of Millions to Hold Us Back and Raising Hell. In 2006, Time included it on their list of the 100 greatest albums of all time.

Proposed top-level domain

The Domain Name System of the Internet consists of a set of top-level domains which constitute the root domain of the hierarchical name space and database. In the growth of the Internet, it became desirable to expand the set of initially six generic top-level domains in 1984. As a result new top-level domain names have been proposed for implementation by ICANN. Such proposals included a variety of models ranging from adoption of policies for unrestricted gTLDs that could be registered by anyone for any purpose, to chartered gTLDs for specialized uses by specialized organizations. In October 2000, ICANN published a list of proposals for top-level domain strings it had received.

Geographic proposals

MED28

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene. It forms part of the Mediator complex.

Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.

Interactions

MED28 has been shown to interact with Merlin,Grb2 and MED26.

See also

References

This article incorporates text from the public domain Pfam and InterPro IPR021640

Further reading

MED6

Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex. It is an enzyme that in humans is encoded by the MED6 gene.

Protein family

This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans.

Interactions

MED6 has been shown to interact with:

References

Further reading

External links

This article incorporates text from the public domain Pfam and InterPro IPR007018