Ago

Ago or AGO may refer to:

People

Places

Other uses

Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Insanity

Insanity, craziness or madness is a spectrum of behaviors characterized by certain abnormal mental or behavioral patterns. Insanity may manifest as violations of societal norms, including a person becoming a danger to themselves or others, though not all such acts are considered insanity; likewise, not all acts showing indifference toward societal norms are acts of insanity. In modern usage, insanity is most commonly encountered as an informal unscientific term denoting mental instability, or in the narrow legal context of the insanity defense. In the medical profession the term is now avoided in favor of diagnoses of specific mental disorders; the presence of delusions or hallucinations is broadly referred to as psychosis. When discussing mental illness in general terms, "psychopathology" is considered a preferred descriptor.

In English, the word "sane" derives from the Latin adjective sanus meaning "healthy". Juvenal's phrase mens sana in corpore sano is often translated to mean a "healthy mind in a healthy body". From this perspective, insanity can be considered as poor health of the mind, not necessarily of the brain as an organ (although that can affect mental health), but rather refers to defective function of mental processes such as reasoning. Another Latin phrase related to our current concept of sanity is "compos mentis" (lit. "sound of mind"), and a euphemistic term for insanity is "non compos mentis". In law, mens rea means having had criminal intent, or a guilty mind, when the act (actus reus) was committed.

Insanity (album)

Insanity is the second full-length studio album from melodic death metal band Darkane, released on March 6, 2001. It is the first Darkane album with Andreas Sydow in the band. The Album's Name came from the Chaotic Events that happened while Recording the album such as a Storm that caused a Power Outage. "Calamitas" is latin for, loss.

Track listing

Credits

Classical participants

References

Togetherness (TV series)

Togetherness is an American comedy-drama television series created by Mark Duplass, Jay Duplass and Steve Zissis. The show's first season premiered on HBO on January 11, 2015. The series has been renewed for an eight-episode second season, which will premiere on February 21, 2016.

Cast

Main

Recurring

Episodes

Season 1 (2015)

Season 2

Reception

The first season received positive reviews from many critics. Review aggregator Rotten Tomatoes gave the first season a 92% approval rating, with an average rating of 7.7 out of 10 based on 37 critic reviews. The critical consensus reads: "Togetherness is a delightful surprise that interweaves day-to-day life with moving, dramatic characters who have an affinity for deprecating, squirmy humor."Metacritic gave the first season a score of 79 based on 23 critic reviews, indicating "generally favorable reviews".IGN reviewer Matt Fowler gave the entire first season an 8.3 out of 10, saying that "The Duplass brothers, along with several wonderful performances, have managed to take an oft-trodden road and paved it fresh."