ING1

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.

Function

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

    • Interactions

    ING1 has been shown to interact with:

  • CREB binding protein,
  • DMAP1,
  • HDAC1,
  • P53,
  • PCNA,
  • SAP30,
  • SIN3A,
  • SMARCA4, and
  • SMARCC1.

    • References

    Further reading

    External links

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    This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/ING1

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    War

    by: Yannick Noah

    What life has taught me
    I would like to share with
    Those who want to learn...
    Until the philosophy which hold one race
    Superior and another inferior
    Is finally and permanently discredited and abandoned
    Everywhere is war, me say war
    That until there are no longer first class
    And second class citizens of any nation
    Until the colour of a man's skin
    Is of no more significance than the colour of his eyes
    Me say war
    That until the basic human rights are equally
    Guaranteed to all, without regard to race
    Dis a war
    That until that day
    The dream of lasting peace, world citizenship
    Rule of international morality
    Will remain in but a fleeting illusion
    To be persued, but never attained
    Now everywhere is war, war
    And until the ignoble and unhappy regimes
    that hold our brothers in Angola, in Mozambique,
    South Africa sub-human bondage
    Have been toppled, utterly destroyed
    Well, everywhere is war, me say war
    War in the east, war in the west
    War up north, war down south
    War, war, rumours of war
    And until that day, the African continent
    Will not know peace, we Africans will fight
    We find it necessary and we know we shall win
    As we are confident in the victory
    Of good over evil, good over evil, good over evil




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