Hereditary multiple exostoses
Hereditary multiple exostoses (HME or MHE), also known as Diaphyseal aclasis, is a rare medical condition in which multiple bony spurs or lumps (also known as exostoses, or osteochondromas) develop on the bones of a child. HME is synonymous with Multiple hereditary exostoses and Multiple osteochondromatosis, which is the preferred term used by the World Health Organization.
Pathophysiology
It is characterized by the growth of cartilage-capped benign bone tumours around areas of active bone growth, particularly the metaphysis of the long bones. Typically five or six exostoses are found in upper and lower limbs. Most common locations are:
HME can lead to the shortening and bowing of bones; affected individuals often have a short stature. Depending on their location the exostoses can cause the following problems: pain or numbness from nerve compression, vascular compromise, inequality of limb length, irritation of tendon and muscle, Madelung's deformity as well as a limited range of motion at the joints upon which they encroach. A person with HME has an increased risk of developing a rare form of bone cancer called chondrosarcoma as an adult. Problems may be had in later life and these could include weak bones and nerve damage. The reported rate of transformation ranges from as low as 0.57% to as high as 8.3% of people with HME.
PowerUp Forever
PowerUp Forever is a downloadable multi-directional shooter developed by Blitz Arcade and published by Namco Bandai for the Xbox 360 via Xbox Live Arcade and the PlayStation 3 via PlayStation Network. It was released on Xbox Live Arcade on December 10, 2008 and the PlayStation Network on December 11, 2008. The title is a reference to the game Warning Forever, which was one of the influences for the game (the others being Geometry Wars and Katamari Damacy.)
Gameplay
The player controls a ship, with dual analog controls similar to Robotron 2084 and Geometry Wars; the left thumbstick controls the ship's movement, while the right thumbstick aims the weapon. The player flies in a fluidic space, trying to kill parasites to attract the level boss. Killing the boss awards the player a new ability, such as lasers, plasma arcs, shields and upgraded weaponry.
Killing the boss causes the player's ship to grow, causing former enemies to shrink and introducing new enemies from the background to the fore, similar to Spore's Cellular phase.
Podcasts:
