Indel

Indel is a molecular biology term for the insertion or the deletion of bases in the DNA of an organism. It has slightly different definitions between its use in evolutionary studies and its use in germ-line and somatic mutation studies.

  • In evolutionary studies, indel is used to mean an insertion or a deletion and indels simply refers to the mutation class that includes both insertions, deletions, and the combination thereof, including insertion and deletion events that may be separated by many years, and may not be related to each other in any way.
  • In germline and somatic mutation studies, indel describes a special mutation class, defined as a mutation resulting in both an insertion of nucleotides and a deletion of nucleotides which results in a net change in the total number of nucleotides, where both changes are nearby on the DNA. A microindel is defined as an indel that results in a net change of 1 to 50 nucleotides.
  • In coding regions of the genome, unless the length of an indel is a multiple of 3, it will produce a frameshift mutation. For example, a common microindel which results in a frameshift causes Bloom syndrome in the Japanese population. Indels can be contrasted with a point mutation. An indel inserts and deletes nucleotides from a sequence, while a point mutation is a form of substitution that replaces one of the nucleotides without changing the overall number in the DNA. Indels can also be contrasted with Tandem Base Mutations (TBM), which may result from fundamentally different mechanisms. A TBM is defined as a substitution at adjacent nucleotides (primarily substitutions at two adjacent nucleotides, but substitutions at three adjacent nucleotides have been observed.

    Indel (rural locality)

    Indel (Russian: Индель) is a rural locality (an inhabited locality) in Tersky District of Murmansk Oblast, Russia, located beyond the Arctic Circle on the Kola Peninsula at a height of 125 meters (410 ft) above sea level. Population: 0 (2010 Census).

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  • Мурманская областная Дума. Закон №545-01-ЗМО от 8 декабря 2004 г. «О статусе, наименованиях и составе территорий муниципального образования Терский район и муниципальных образований, входящих в его состав». Вступил в силу 1 января 2005 г. Опубликован: "Мурманский Вестник", №238, стр. 3, 15 декабря 2004 г. (Murmansk Oblast Duma. Law #545-01-ZMO of December 8, 2004 On the Status, Names, and Composition of the Territories of the Municipal Formation of Tersky District and of the Municipal Formations It Comprises. Effective as of January 1, 2005.).

  • Delhi

    Delhi (/ˈdɛli/, Hindustani pronunciation: [d̪ɪlliː] Dilli), officially the National Capital Territory of Delhi, is the capital territory of India. Delhi is historically and culturally connected to both the Upper Doab of the Yamuna-Ganges river system and the Punjab region. It is bordered by Haryana on three sides and by Uttar Pradesh to the east. It is the largest city in India in terms of geographical area - about 1,484 square kilometres (573 sq mi). It has a population of about 16.3 million, making it the second most populous city and second most populous urban agglomeration in India and 3rd largest urban area in the world. Such is the nature of urban expansion in Delhi that its growth has expanded beyond the NCT to incorporate towns in neighbouring states and at its largest extent can count a population of about 25 million residents as of 2014.

    Delhi has been continuously inhabited since the 6th century BC. Through most of its history, Delhi has served as a capital of various kingdoms and empires. It has been captured, ransacked and rebuilt several times, particularly during the medieval period, and modern Delhi is a cluster of a number of cities spread across the metropolitan region.

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