In silico

In silico (literally Latin for "in silicon", alluding to the mass use of silicon for semiconductor computer chips) is an expression used to mean "performed on computer or via computer simulation." The phrase was coined in 1989 as an allusion to the Latin phrases in vivo, in vitro, and in situ, which are commonly used in biology (see also systems biology) and refer to experiments done in living organisms, outside of living organisms, and where they are found in nature, respectively.

Drug discovery with virtual screening

In silico study in medicine is thought to have the potential to speed the rate of discovery while reducing the need for expensive lab work and clinical trials. One way to achieve this is by producing and screening drug candidates more effectively. In 2010, for example, using the protein docking algorithm EADock (see Protein-ligand docking), researchers found potential inhibitors to an enzyme associated with cancer activity in silico. Fifty percent of the molecules were later shown to be active inhibitors in vitro. This approach differs from use of expensive high-throughput screening (HTS) robotic labs to physically test thousands of diverse compounds a day often with an expected hit rate on the order of 1% or less with still fewer expected to be real leads following further testing (see drug discovery).

In silico (disambiguation)

In silico is an expression meaning "performed on computer or via computer simulation".

In silico may also refer to:

See also

In Silico (Deepsky album)

In Silico is a full length artist album by the American electronic music group Deepsky. It was released in 2002. The title refers to the largely computer-based production methods employed during the album's creation, where the bulk of the music was composed using virtual instruments and Emagic Logic Audio 5 rather than external hardware synthesizers and traditional multi-track recorders.

The website AllMusic gave In Silico three stars out of a possible five, with reviewer John Bush stating that the album "has it all: the low attention span of funky breaks, the streamlined groove of progressive trance, even the intelligent production and frequent changeups of techno."

Track listing