Hughes Mining Barge
The Hughes Mining Barge, or HMB-1, is a submersible barge about 99 m (324 ft) long, 32 m (106 ft) wide, and more than 27 m (90 ft) tall. The HMB-1 was originally developed as part of Project Azorian (more widely, but erroneously, known as "Project Jennifer"), the top-secret effort mounted by the Central Intelligence Agency to salvage the remains of the Soviet submarine K-129 from the ocean floor.
The HMB-1 was designed to allow the device that would be used to grasp and lift the submarine to be constructed inside the barge and out of sight, and to be installed in the Glomar Explorer in secrecy. This was done by towing the HMB-1, with the capture device inside, to a location near Catalina Island (off the coast of California), and then submerging it onto stabilizing piers that had been installed on the seafloor. The Glomar Explorer was then maneuvered over the HMB-1, the retractable roof was opened, and the capture device lifted into the massive "moon pool" of the ship, all within clear sight of people on the beach.
HMB-45
HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas, and stands for human melanoma black 45. It is used in anatomic pathology as a marker for such tumors. The specific antigen recognized by HMB-45 is now known as Pmel 17.
HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. The antibody was generated to an extract of melanoma. It reacts positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity.
In a study to determine diagnostic usefulness of specific antibodies used to identify melanoma, HMB-45 had a 92% sensitivity when used to identify melanoma. The antibody also reacts positively against junctional nevus cells and fetal melanocytes.
Despite this relatively high sensitivity—HMB-45 does have its drawbacks. HMB-45 can be detected in only 50-70% of melanomas. HMB-45 does not react well against intradermal nevi, normal adult melanocytes, spindle cell melanomas and desmoplastic melanomas. HMB-45 is nonreactive with almost all non-melanoma human malignancies, with the exception of rare tumors showing evidence of melanogenesis (e.g., pigmented schwannoma, clear cell sarcoma) or tumors associated with tuberous sclerosis complex (angiomyolipoma and lymphangiomyoma).
Console (video game CLI)
A console is a command line interface where the personal computer game's settings and variables can be edited while the game is running. Consoles also usually display a log of warnings, errors, and other messages produced during the program's execution. Typically it can be toggled on or off and appears over the normal game view.
The console is normally accessed by pressing the backtick key ` (frequently also called the ~ key; normally located below the ESC key) on QWERTY keyboards or the ² on AZERTY keyboards, and is usually hidden by default. In most cases it cannot be accessed unless enabled by either specifying a command line argument when launching the game or by changing one of the game's configuration files.
History
A classic console is a box that scrolls down from the top of the screen, and is found in most computer games. This style was made popular with Quake (1996). There are other forms of console:
Impulse (software company)
Impulse, Inc. is a software company responsible for making several 3D modeling and rendering applications. Most notably TurboSilver and Imagine for the Amiga computer. They were originally located in Minneapolis, Minnesota and later moved to Las Vegas, Nevada. After moving to Las Vegas they became more and more involved in creating software for casino video slot machines.
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Science Fantasy (magazine)
Science Fantasy, which also appeared under the titles Impulse and SF Impulse, was a British fantasy and science fiction magazine, launched in 1950 by Nova Publications as a companion to Nova's New Worlds. Walter Gillings was editor for the first two issues, and was then replaced by John Carnell, the editor of New Worlds, as a cost-saving measure. Carnell edited both magazines until Nova went out of business in early 1964. The titles were acquired by Roberts & Vinter, who hired Kyril Bonfiglioli to edit Science Fantasy; Bonfiglioli changed the title to Impulse in early 1966, but the new title led to confusion with the distributors and sales fell, though the magazine remained profitable. The title was changed again to SF Impulse for the last few issues. Science Fantasy ceased publication the following year, when Roberts & Vinter came under financial pressure after their printer went bankrupt.
