IMPA may refer to:
Inositol monophosphatase 1 is an enzyme that in humans is encoded by the IMPA1 gene.
IMPA1 has been shown to interact with Bergmann glial S100B and calbindin.
L-690,330 is a competitive inhibitor of IMPase activity with very good activity in vitro however with limited bioavailability in vivo. Due to its increased specificity compared to Lithium, L-690,330 has been used extensively in characterizing the results of IMPase inhibition in various cell culture models. L-690,488, a prodrug or L-690,330, has also been developed which has greater cell permeability. Treatment of cortical slices with L-690,488 resulted in accumulation of inositol demonstrating the activity of this inhibitor in tissue.
Inhibition of IMPA1 activity can have pleiotropic effects on cellular function, including altering phosphoinositide signalling,autophagy, apoptosis, and other effects.
Initially it was noticed that several drugs useful in treatment of biopolar disorder such as lithium, carbamazepine and valproic acid had a common mechanism of action on enzymes in the phosphatidylinositol signalling pathway and the inositol depletion hypothesis for the pathophysiology of biopolar disorder was suggested. Intensive research has so far not confirmed this hypothesis, partly because lithium can also act on a number of other enzymes in this pathway, complicating results from in vitro studies.
Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene. IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.
The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.
Otis:
Did I really take her and keep her with me?
Cover her face up so she couldn't breathe?
Cut her eyeballs out so she couldn't see?
I still feel like she is looking at me.
Brought her to the basement and took off her clothes
Did I do the right thing?
God only knows!
Chorus x 4:
Maybe I was only wondering if I could open up your body
Take your heart out and consume
("God only knows!" throughout chorus)
Otis:
Am I really like this? Is this really me?
Am I really the person I want to be?
Is it this life that has created me?
Am I a product of society?
Did I really eat pills cause everything's fucked?!
Can I fall asleep and just never wake up?!!
Chorus x 4:
Maybe I was only wondering if I could open up your body
Take your heart out and consume