Argonaute

The Argonaute protein family plays a central role in RNA silencing processes, as essential catalytic components of the RNA-induced silencing complex (RISC). RISC complex is responsible for the gene silencing phenomenon known as RNA interference (RNAi). Argonaute proteins bind different classes of small non-coding RNAs, including microRNAs (miRNAs), small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). Small RNAs guide Argonaute proteins to their specific targets through sequence complementarity (base pairing), which then leads to mRNA cleavage or translation inhibition.

Discovery

The RNA interference (RNAi) was first reported in 1995 by Guo and Kemphues, and similar pathways collectively referred to as RNA silencing were discovered in plants and fungi. The beginning of people’s understanding of the mechanism of RNA silencing began only in 1998 with the experiments of Fire and colleagues demonstrating that double-stranded RNA triggered RNAi. RNA silencing pathways process long RNAs into small RNAs that direct the repression of transcription or translation of nucleic acid targets with sequence corresponding to the small RNAs. These single-stranded RNAs, referred to as guide strands, are incorporated into RNA silencing effectors complexes such as the RNA-induced silencing complex (RISC). These RNA silencing effector complexes contain Argonaute family proteins.

Illusion

An illusion is a distortion of the senses, revealing how the brain normally organizes and interprets sensory stimulation. Though illusions distort reality, they are generally shared by most people. Illusions may occur with any of the human senses, but visual illusions (optical illusions), are the most well-known and understood. The emphasis on visual illusions occurs because vision often dominates the other senses. For example, individuals watching a ventriloquist will perceive the voice is coming from the dummy since they are able to see the dummy mouth the words. Some illusions are based on general assumptions the brain makes during perception. These assumptions are made using organizational principles (e.g., Gestalt theory), an individual's capacity for depth perception and motion perception, and perceptual constancy. Other illusions occur because of biological sensory structures within the human body or conditions outside of the body within one’s physical environment.

The term illusion refers to a specific form of sensory distortion. Unlike a hallucination, which is a distortion in the absence of a stimulus, an illusion describes a misinterpretation of a true sensation. For example, hearing voices regardless of the environment would be a hallucination, whereas hearing voices in the sound of running water (or other auditory source) would be an illusion.

Faith Hill

Faith Hill (born Audrey Faith Perry; September 21, 1967) is an American country pop singer and occasional actress. She is one of the most successful country artists of all time, having sold more than 40 million albums worldwide. Hill is married to country singer Tim McGraw, with whom she has recorded several duets.

Hill's first two albums, Take Me as I Am (1993) and It Matters to Me (1995), were major successes and placed a combined three number ones on Billboard's country charts. She then achieved mainstream and crossover success with her next two albums, Faith (1998) and Breathe (1999). Faith spawned her first international hit, "This Kiss", and went multi-platinum in various countries. Breathe became her best-selling album to date and one of the best-selling country albums of all time, with the huge crossover success of the songs "Breathe" and "The Way You Love Me". It had massive sales worldwide and earned Hill three Grammy Awards, including Best Country Album.

In 2001, she recorded "There You'll Be" for the Pearl Harbor soundtrack and it became an international hit and her best-selling single in Europe. Hill's next two albums, Cry (2002) and Fireflies (2005), were both commercial successes and kept her mainstream popularity; the former spawned another crossover single, "Cry", which won Hill a Grammy Award, and the latter produced the hit singles "Mississippi Girl" and "Like We Never Loved at All", which earned her another Grammy Award.

Illusion (series)

The Illusion series, known in Japan as I Love Mickey Mouse, is a series of platforming video games licensed by Disney and developed/published by Sega exclusively for its consoles Master System, Mega Drive and Game Gear. The series follows the adventures of Disney's cartoon character Mickey Mouse (sometimes with Donald Duck) between various fantasy worlds. The series includes Castle of Illusion, and its sequels Land of Illusion, World of Illusion and Legend of Illusion. The first two games and the last game were released for Master System and Game Gear, and the first game and the third game were released for Mega Drive.

Games

Main series

Related games

Characters

See also

References