IL2RB

Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene.

Function

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

Interactions

IL2RB has been shown to interact with:

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.