C1orf38

Chromosome 1 open reading frame 38 is a protein that in humans is encoded by the C1orf38 gene. The gene is also known as ICB-1 and THEMIS2 in humans, and the orthologue in mice is BC013712. C1orf38 has been associated with cancer susceptibility.

Model organisms

Model organisms have been used in the study of C1orf38 function. A conditional knockout mouse line, called BC013712tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on mutant mice and one significant abnormality was observed: chromosomal instability was detect by a micronucleus test.

References

Further reading


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ICB

by: New Order

My love falls from heaven
To talk of this strange design
Then it goes forever
Where all things never die
People look whenever
These races have been won
Minds just for breathing
When the means for this have begun
It's so far away, and it's closing in
It's so far away, and it seems to travel in
Taken from the killing ground
By all dividing hands
With no sense or reason,
They came, they found, they ran
Taking good advantage of
All the things they are told
I washed my hands of innocence
When you started taking control
It's so far away, and it's closing in




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