Interstate 59 (I-59) is an Interstate Highway in the southern United States. Its southern terminus is near Slidell, Louisiana, a northeastern suburb of New Orleans, at its interchange with I-10 and I-12, and its northern terminus is at Wildwood, Georgia, at its interchange with I-24. The highway's major purpose is to connect Chattanooga, Tennessee, and points north, with New Orleans via Birmingham, Alabama. Along its entire route, I-59 is parallel to U.S. Route 11 (US 11). I-59 is a four-lane freeway along its entire route except for some portions north of Tuscaloosa, Alabama and in the Birmingham, Alabama, metropolitan area, where it is several lanes wider.
About a third of the entire route overlaps with Interstate 20 between Birmingham, Alabama and Meridian, Mississippi.
In the U.S. state of Louisiana, I-59 is shorter than it is in any other state: Alabama, Mississippi, and Georgia. From south-to-north, I-59 begins at its junction with I-10 and I-12 near Slidell. Then it bypasses Pearl River before crossing the West Pearl River and then the East Pearl River. At the East Pearl River, I-59 leaves St. Tammany Parish and it enters Pearl River County, Mississippi.