ITI-007
ITI-007 is an investigational atypical antipsychotic which is currently under development by Intra-Cellular Therapies, licensed from Bristol-Myers Squibb, for the treatment of schizophrenia. It is also being developed by Intra-Cellular Therapies for the treatment of bipolar disorder, depression, and sleep and behavioral disturbance in dementia, autism, and other neuropsychiatric disorders. As of September 2015, ITI-007 has passed the first of two phase III clinical trials for schizophrenia.
Pharmacodynamics
Relative to presently-available antipsychotics, ITI-007 possesses a unique and novel mechanism of action. It acts as a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM). It also possesses affinity for the D1 receptor (Ki = 52 nM) and weak affinity for the α1A- and α1B-adrenergic receptors (Ki = 173 nM at α1) and D4 receptor. ITI-007 does not significantly bind to the 5-HT2B, 5-HT2C, H1, or mACh receptors.
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Braindead Hero
by: UdoFor a long time he's been lucky man
No difference if it's good or bad
The trigger's his - the orders others
No way to stop the final blow
The message: here ya go
The countdown's on a roll
War against the world
All systems deadly armed
Machine, man, all in one
They're all oblivious to the crime
Braindead hero
Braindead hero - out of the sun he comes
Braindead hero
Braindead hero - feel the blazing guns
Now we got to blow his circuitry
Drain the poison from his veins
Degenerate - corrupt his memories
Fire at will - just do or die
The message: here ya go
The countdown's on a roll
War against the world
All systems deadly armed
Machine, man, all in one
They're all oblivious to the crime
Braindead hero
Braindead hero -like a hammer from the sky
Braindead hero
Braindead hero - supersonic cry
You better stay just where you are
Consequences in the fire
Braindead hero
Braindead hero - out of the sun he comes
Braindead hero