Iroquois homeobox 3
Identifiers
Symbols IRX3; IRX-1; IRXB1
External IDs OMIM612985 MGI1197522 HomoloGene7385 GeneCards: IRX3 Gene
Orthologs
Species Human Mouse
Entrez 79191 16373
Ensembl ENSG00000177508 ENSMUSG00000031734
UniProt P78415 P81067
RefSeq (mRNA) NM_024336.2 NM_001253822.1
RefSeq (protein) NP_077312.2 NP_001240751.1
Location (UCSC) Chr 16:
54.32 – 54.32 Mb
Chr 8:
94.32 – 94.33 Mb
PubMed search [1] [2]

Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.[1]

Function [link]

IRX3 is a member of the Iroquois homeobox gene family and plays a role in an early step of neural development.[2] Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1][3]

References [link]

  1. ^ a b "Entrez Gene: iroquois homeobox 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79191. 
  2. ^ Bellefroid EJ, Kobbe A, Gruss P, Pieler T, Gurdon JB, Papalopulu N (January 1998). "Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification". EMBO J. 17 (1): 191–203. DOI:10.1093/emboj/17.1.191. PMC 1170370. PMID 9427753. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170370. 
  3. ^ Lewis MT, Ross S, Strickland PA, Snyder CJ, Daniel CW (June 1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. DOI:10.1007/s004410051316. PMID 10370142. 

Further reading [link]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



https://wn.com/IRX3

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