Internet Relay Chat

Internet Relay Chat (IRC) is an application layer protocol that facilitates communication in the form of text. The chat process works on a client/server networking model. IRC clients are computer programs that a user can install on their system. These clients communicate with chat servers to transfer messages to other clients. IRC is mainly designed for group communication in discussion forums, called channels, but also allows one-on-one communication via private messages as well as chat and data transfer, including file sharing.

Client software is available for every major operating system that supports Internet access. As of April 2011, the top 100 IRC networks served more than half a million users at a time, with hundreds of thousands of channels operating on a total of roughly 1,500 servers out of roughly 3,200 servers worldwide.

IRC usage has been declining since 2003, losing 60% of its users (from 1 million to about 400,000 in 2014) and half of its channels (from half a million in 2003).

Setmelanotide

Setmelanotide (INN, USAN) (code name RM-493, formerly BIM-22493, IRC-022493) is a peptide drug and investigational anti-obesity medication which acts as a selective agonist of the MC4 receptor. Its peptide sequence is Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2. It is being researched by Rhythm Pharmaceuticals for the treatment of obesity and diabetes. In addition, Rhythm Pharmaceuticals is conducting trials of setmelanotide for the treatment of Prader–Willi syndrome (PWS), a genetic disorder which includes MC4 receptor deficiency and associated symptoms such as excessive appetite and obesity. As of December 2014, the drug is in phase II clinical trials for obesity and PWS.

Setmelanotide binds to and activates MC4 receptors in the paraventricular nucleus (PVN) of the hypothalamus and in the lateral hypothalamic area (LHA), areas involved in the regulation of appetite, and this action is thought to underlie its appetite suppressant effects. In addition to reducing appetite, setmelanotide increases resting energy expenditure in both obese animals and humans. Importantly, unlike certain other MC4 receptor agonists, such as LY-2112688, setmelanotide has not been found to produce increases in heart rate or blood pressure.

Nu Aquilae

Nu Aquilae (ν Aql, ν Aquilae) is the Bayer designation for a double star in the constellation of Aquila and lies close to the celestial equator. It has an apparent visual magnitude of 4.72 and so is visible to the naked eye.

The spectrum of ν Aql A matches a stellar classification of F3, with the luminosity class of Ib indicating this is a supergiant. It has over twelve times the mass of the Sun and 78 times the Sun's radius. The outer atmosphere has an effective temperature of 6,900 K and it is radiating 11,800 times as much light as the Sun. At this heat, it has the yellow-white hue of an F-type star. Based upon an annual parallax shift of only 1.15 mas (with a 23% margin of error), it is approximately 2,800 light-years (860 parsecs) from Earth.

ν Aql B is a tenth magnitude star 220 arc-seconds distant. Little is known about it except an approximate spectral classification

References

External links

  • Image ν Aquilae
  • HR 7387
  • CCDM 19265+0021
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    Latest News for: irc

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    Ninety Days Since Last Refugee Arrivals, Refugee Families and Resettlement Program Remains in Limbo (IRC - International Rescue Committee Inc)

    Public Technologies 21 Apr 2025
    IRC Global Communications ... Despite challenges due to the sudden changes to the resettlement program, with the help of IRC case workers, the woman found full-time employment at a large retailer and enrolled her son in school.
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    Man stabbed outside the IRC this morning

    News & Record 18 Apr 2025
    A man stabbed outside the IRC this morning and sustained non-life-threatening injuries ... .
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    IRCS, IFRC discuss ways to address regional challenges

    Tehran Times 18 Apr 2025
    TEHRAN – The Iranian Red Crescent Society (IRCS) and the International Federation of the Red Cross and the Red Crescent Societies (IFRC) have explored the potential to foster joint activities for dealing with regional challenges ... .
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    United Way of IRC concludes speaker series with a focus on second chances

    TCPalm 13 Apr 2025
    VERO BEACH — United Way of Indian River County’s final Powered by Purpose. Speaker Series event of the season delivered a powerful conversation on second chances and the challenges justice-involved individuals face upon reentry into society.
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    Two years of conflict in Sudan: IRC recommends action for catastrophic humanitarian and diplomatic failure (IRC - International Rescue Committee Inc)

    Public Technologies 10 Apr 2025
    IRC policy paper sets out analysis of why the conflict persists and recommendations for solutions ... IRC Global Communications ... Anne Marie Schryer, IRC East Africa Advocacy Coordinator said, ... IRC's policy paper sets out detailed recommendations on.
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    Sudan: Two years of war, starvation & global failure, the world must act now (IRC - International Rescue Committee Inc)

    Public Technologies 10 Apr 2025
    ) Media contacts. Madiha Raza. International Rescue Committee. madiha.raza@rescue.org. IRC Global Communications. +1 646 761 0307. communications@rescue.org ... Attacks on civilians are relentless ... This cannot go on ... IRC - International Rescue Committee Inc.
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    The IRC calls for the immediate protection of aid workers in Gaza, following the killing of partner health workers (IRC - International Rescue Committee Inc)

    Public Technologies 09 Apr 2025
    IRC Global Communications ... The doctor and nurse were returning from work at an IRC-supported medical point where they were providing essential medical treatment. Zoe Daniels, IRC's Country Director in the occupied Palestinian territory, says,.
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    LIVE UPDATES: At least 20 Palestinians killed as Israeli jets bomb family home in Gaza City

    Middle East Monitor 08 Apr 2025
    A medical source said that 20 people were killed and more than 50 others injured in the attack ....
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    Ravensource Fund IRC Annual Report to Securityholders 2024 (Ravensource Fund)

    Public Technologies 06 Apr 2025
    This report summarizes the IRC's activities over 2024 ... Since inception of the IRC in 2007, IRC members have been indemnified by the Fund under the IRC charter as well as under section 13.4.1 of the Declaration of Trust.
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    The IRC is deeply concerned by new wave of forced displacement amid military escalation in Gaza (IRC - International Rescue Committee Inc)

    Public Technologies 04 Apr 2025
    IRC Global Communications ... Amman, Jordan, April 4, 2025 - Zoe Daniels, IRC's Country Director for the occupied Palestinian territory, says, ... "IRC staff on the ground are witnessing the crisis unfold in real time.
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