ING4

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.

Interactions

ING4 has been shown to interact with EP300,RELA and P53.

References

Further reading

External links

  • ING4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

    • This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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    What life has taught me
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    Until the philosophy which hold one race
    Superior and another inferior
    Is finally and permanently discredited and abandoned
    Everywhere is war, me say war
    That until there are no longer first class
    And second class citizens of any nation
    Until the colour of a man's skin
    Is of no more significance than the colour of his eyes
    Me say war
    That until the basic human rights are equally
    Guaranteed to all, without regard to race
    Dis a war
    That until that day
    The dream of lasting peace, world citizenship
    Rule of international morality
    Will remain in but a fleeting illusion
    To be persued, but never attained
    Now everywhere is war, war
    And until the ignoble and unhappy regimes
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    South Africa sub-human bondage
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    War, war, rumours of war
    And until that day, the African continent
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    We find it necessary and we know we shall win
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    Of good over evil, good over evil, good over evil




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