Imbé

Imbé is a municipality on the coastline of Rio Grande do Sul, the southernmost state of Brazil, 120 km (75 statute miles) east of Porto Alegre.

Its population is approximately 14 thousand. It has warm summers (average temperature 22 °C (72 °F) in January) and cool winters (14 °C (57 °F) in July).

Imbé separated from its neighbouring city, Tramandaí, in 1988. In that same year, many small municipalities were created in Rio Grande do Sul.

IMB

IMB is a three-letter abbreviation that may refer to:

KPNB1

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.

Function

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a classical nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits. Each of these subunits are part of the karyopherin family of proteins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.