ILF2

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.

Function

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.

Interactions

ILF2 has been shown to interact with CDC5L and DNA-PKcs.

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.