IL-7 receptor and signaling, common γ chain (blue) and IL-7 receptor-α (green)

interleukin 2 receptor, gamma
Identifiers
Symbol	IL2RG
Alt. symbols	SCIDX1, IMD4, CD132
Entrez	3561
HUGO	6010
OMIM	308380
RefSeq	NM_000206
UniProt	P31785
Other data
Locus	Chr. X q13

The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).^{[1] [2]} The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15. Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.

Function [link]

Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination^{[citation needed]}. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation^{[citation needed]}. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).^[3]

Diseases [link]

Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia, ^[4], multiple sclerosis,^[5] rheumatoid arthritis and juvenile idiopathic arthritis.^[6]

See also [link]

• Cluster of differentiation

References [link]

External links [link]

• IL7R+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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