IL36G

Interleukin-36 gamma also known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene.

Function

The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. IL36G expression has been linked to psoriasis lesions and has been used as a biomarker for differentiating between eczema and psoriasis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

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Further reading